Fluoride-treated synthetic material enables dental bone regeneration

A fluoride solution applied to bio-resorbable synthetic hydroxyapatite granules—a bone supplement material—promotes bone regeneration, say findings of a study reported in the April issue of Journal of Oral Implantology.

The study’s authors conclude that application of the fluoride solution to resorbable HA granules spurs a process leading to bone cell adhesion, proliferation and differentiation, thereby enabling osteogenesis.

In reporting on the study, the Journal of Oral Implantology examined the usefulness of the method in shoring up jaw bone for successful dental implant.

Previous studies of fluoridated HA focused on spurring slow-release fluoride for caries prevention, whereas this study was carried out toward bone regrowth, the article points out. “The present study aimed to investigate the biologic effects of released fluoride from the surface of fluoridated resorbable HA granules on MG-63 human osteoblastic cells,” the article said.

The full text of the article, “Fluoride-treated bio-resorbable synthetic hydroxyapatite promotes proliferation and differentiation of human osteoblastic MG-63 Cells” can be accessed for free in the Journal of Oral Implantology, the official publication of the American Academy of Implant Dentistry and of the American Academy of Implant Prosthodontics.

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